薬理系3 (薬生体内で生み出される生理活性物質)/薬理系6 (薬と病態・精神疾患)/薬理系7 (薬と病態・神経・筋疾患)/薬と病態チュートリアルⅠ(神経疾患)/医薬品毒性学、/新薬概論、/薬理学実習

主な研究テーマ

1. シナプス可塑性とうつ病を引き起こす脳内神経回路について
2. PTSDとトラウマ記憶の汎化を制御するコーピング方略決定機序について
3. 精神的ストレスに対するレジリエンス獲得と積極的コーピングについて
4. 精神的ストレスに及ぼす香りの効果と心理的影響について

 

最近の主な研究論文

奥羽大学で行った研究の学術論文 (2014年～)

1. Yuka Tamura, Sakura Maeda, Haruna Takahashi, Yuta Aoto, Tohru Matsuki, Kenjiro Seki^*,  GABAergic circuit interaction between central amygdala and bed nucleus of the stria terminalis in lipopolysaccharide-induced despair-like behavior, Physiol Behav., 2024, 288:114753, PMID:39551417, ^*Corresponding author.

2. Rino Hashimoto, Toshiya Murakami, Ryuma Kamimura, Tohru Matsuki, Kenjiro Seki^*,  High salt intake induces active coping behaviors by enhancing the resilience against psychological stress in mice, J Integr Neurosci. , 2022, 21(6):173., PMID: 36424754, ^*Corresponding author.

3. Emi Kasama, Miho Moriya, Ryuma Kamimura, Tohru Matsuki, Kenjiro Seki^* Formation of False Context Fear Memory Is Regulated by Hypothalamic Corticotropin-Releasing Factor in Mice., Int J Mol Sci, 2022, 23(11): 6286., PMID: 35682965, ^*Corresponding author. 

4. Nao Fukuwada, Miki Kannno, Satomi Yoshida, Kenjiro Seki^* Gαq protein signaling in the bed nucleus of the stria terminalis regulate the lipopolysaccharide-induced despair-like behavior in mice, AIMS Neuroscience, 2020, 7(4): p.438-458., PMID: 33263080, ^*Corresponding author.

5. 関 健二郎 ^*, 森谷 美穂,  橋本 璃乃,  精神的ストレスに及ぼす香りの効果- オイゲノール芳香によるレジリエンスの獲得とうつ病予防の可能性 -, Aroma Research, 2020, No. 84, Vol/21/No.4, p.307-315., ^*責任著者.

6. Shisui Fujita, Satomi Yoshida, Tohru Matsuki, Manoj K. Jaiswal, Kenjiro Seki^* The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling, Behavioural Pharmacol, 32(1): p.73-85., 2020., PMID: 33164996, ^*Corresponding author.

7. 山梨 穣, 佐藤 佳澄, 関 健二郎 ^*, 心拍変動および脳波、コルチゾール分泌に及ぼすオイゲノール芳香の効果, Aroma Research, No. 82, Vol/21/No.2, p.192-199, 2020, 2020年度・優秀論文賞, ^*責任著者.

8. 佐藤 佳澄,  関 健二郎 ^*, 精神的ストレスに及ぼす香りの効果, Aroma Research, No. 75, Vol. 19/No. 3, p.202-209, 2018, ^*責任著者.

9. Kenjiro Seki, Satomi Yoshida, Manoj K. Jaiswal, Molecular mechanism of noradrenaline during the stress-induced major depressive disorder, Neural. Regen Res., Jul;13(7): p.1159-1169, 2018., PMID:  30028316

10. 関 健二郎 ^*, 香りによるうつ病発症予防の可能性を追求して, Aroma Research, No. 73, Vol. 19/No. 1, p.12-13, 2018, ^*責任著者.

11. Sayori Yashiro and Kenjiro Seki ^* Association of social defeat stress-induced anhedonia-like symptoms with mGluR1-dependent downregulation of membrane AMPA-GluR1 in the mouse ventral midbrain. Stress., Jul; 20(4): p.404-418., 2017., PMID:  28554247, ^*Corresponding author.

12. Koh Shimizu, Natsuki Kurosawa, Kenjiro Seki ^* Chronic social isolation induced down-regulation of serotonin 5-HT3 receptor in hypothalamus is associated with the acceleration of aggressive behavior in mice. Physiol Behav., Jan: 153, p.70-83., 2016., PMID:  26522741, ^*Corresponding author

13. Natsuki Kurosawa, Koh Shimizu, Kenjiro Seki ^* The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice, Psychopharmacology (Berl); 233(9): p.1725-37, 2015, PMID:  26385227, ^*Corresponding author.

14. 佐藤 佳澄, 八代 彩愛, 関 健二郎 ^* 長期隔離飼育マウスの攻撃性獲得と抑うつ症状発症に対するオイゲノール芳香の予防効果, Aroma Research Vol.16/No.4, p.368-375, 2015, 2015年度・論文奨励賞, ^*責任著者.

15. Ryo Ohshima, Kanae Hotsumi, Christian Holscher, Kenjiro Seki ^* Age-related decrease in glucagon-like peptide-1 in mouse prefrontal cortex but not in hippocampus despite the preservation of its receptor, American J. BioSci., Vol. 3, No. 1, p.11-27., 2015, ^*Corresponding author.

16. Miyu Sekio and Kenjiro Seki ^* Lipopolysaccharide-induced depressive-like behavior is associated with α1-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area., Int J Neuropsychopharmacol, 18 (1), p.1-12: 31 Oct. 2014. PMID:  25539502, ^*Corresponding author.

17. Nobuaki Ohtake, Mieko Saito, Masaaki Eto, Kenjiro Seki ^* Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex., Regul Pept. Apr 24; 190-191C: p.1-11., 2014. PMID:  24769307, ^*Corresponding author

 

 

 

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