薬の効き方と作用点/生体内で生み出される生理活性物質/心・血管・呼吸器疾患/腎・泌尿器・生殖器疾患/薬と病態チュートリアル2(循環器疾患、代謝性疾患)/医薬品毒性学/新薬概論/薬理学実習/特別実習

主な研究テーマ

1. 糖尿病モデルラットの臓器障害進展に関与するイオンチャネル遺伝子の解析
2. VEGFR-TKIによる糖尿病ラットの心血管系に及ぼす影響
3. TRPチャネルファミリーの病態生理学的役割の解明

原著論文

1. Effects of Tyrosine Kinase Inhibitors on Blood Pressure in Patients with Unresectable or Advanced Recurrent Renal Cell Carcinoma: Bayes-Mixed Treatment Comparison Meta - Analysis. Shion Yamaguchi, Rumi Murayama, Eisaku Satoh, Tadao Inoue, Yuya Ise.: 癌と化学療法, 2021, 48(9), 1145-1151
2. Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel β3 subunit.  Murakami, M., Ohba, T., Xu, F., Satoh, E., Miyoshi, I., Suzuki, T., Takahashi, Y., Takahashi, E., Watanabe, H., Ono, K., Sasano, H., Kasai, N, Ito, H., Iijima, T.  J. Biol. Chem., 2008, 283(36), 24554-24560.
3. Regulatory role of neuron-restrictive silencing factor in expression of TRPC1.  Ohba, T., Watanabe, H., Takahashi, Y., Suzuki, T., Miyoshi, I., Nakayama, S., Satoh, E., Iino, K., Sasano, H., Mori, Y., Kuromitsu, S., Imagawa, K., Saito, Y., Iijima, T., Ito, H., Murakami, M.  Biochem. Biophys. Res. Commun., 2006, 351(3), 764-770. 
4. Genomic organization and functional analysis of murine PKD2L1.  Murakami, M., Ohba, T., Xu, F., Shida, S., Satoh, E. Ono, K., Miyoshi, I., Watanabe, H., Ito, H., Iijima, T.  J. Biol. Chem., 2005, 280(7), 5626-5635. 
5. Protein kinase C-mediated Ca²⁺ entry in HEK 293 cells transiently expressing human TRPV4.  Xu, F., Satoh, E., Iijima, T.  Br. J. Pharmacol., 2003, 140(2), 413-421. 
6. Identification and characterization of the murine TRPM4 channel.  Murakami, M., Xu, F., Miyoshi, I., Sato, E., Ono, K., Iijima, T.  Biochem. Biophys. Res. Commun., 2003, 307(3), 522-528. 
7. Inhibition by antisense oligonucleotides of plasma membrane Ca²⁺ ATPase in vascular endothelial cells.  Nakao, M., Furukawa, K., Satoh, E., Ono, K., Iijima, T.  Eur. J. Pharmacol., 2000, 387(3), 273-277.
8. Cloning and functional expression of a novel splice variant of rat TRPC4.  Satoh, E., Ono, K., Xu, F., Iijima, T.  Circ. J., 2002, 66(10), 954-958.
9. Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K⁺ channels.  Kondo, C., Repunte, V.P., Satoh, E., Yamada, M., Horio, Y., Matsuzawa, Y., Pott, L., Kurachi, Y.  Receptors Channels, 1998, 6(2), 129-140.
10. Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.  Satoh, E., Yamada, M., Kondo, C., Repunte, V.P., Horio, Y., Iijima, T., Kurachi, Y.  J. Physiol., 1998, 511(3), 663-674.
11. The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K⁺ channel expressed in a mammalian cell line, HEK293T cells.  Okuyama, T., Yamada, M., Kondo, C., Satoh, E., Isomoto, S., Shindo, T., Horio, Y., Kitakaze, M., Hori, M., Kurachi, Y., Pflügers Arch., 1998, 435(5), 595-603
12. Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.  Horio, Y., Hibino, H., Inanobe, A., Yamada, M., Ishii, M., Tada, Y., Satoh, E., Hata, Y., Takai, Y., Kurachi, Y.  J. Biol. Chem., 1997, 272(29), 12885-12888.
13. The affinity of betaxolol, a β1-adrenoceptor-selective blocking agent, for β-adrenoceptors in the bovine trachea and heart.  Satoh, E., Narimatsu, A., Hosohata, Y., Tsuchihashi, H., Nagatomo, T.  Br. J. Pharmacol.  1993, 108(2), 484-489. 
14. Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.  Satoh, E., Yanagisawa, T., Taira, N.  Jpn. J. Pharmacol., 1990, 54(2), 133-141.
15. Inhibitory effects of diltiazem, verapamil, nifedipine, and nicardipine on sympathetic tachycardia in decentralized hearts of anesthetized dogs.  Satoh, E., Mukaiyama, O., Kimura, T., Satoh, S.  J. Cardiovasc. Pharmacol., 1990, 16(4), 661-666.
16. Selective β1-receptor full agonists, T-0509 and T-1583, increase the force monophasically and cyclic AMP biphasically in canine ventricular muscle.  Kurosawa, H., Satoh, E., Yanagisawa, T., Taira, N.  J. Cardiovasc. Pharmacol., 1990, 16(4), 646-653. 
17. Effects of opioid agonists on sympathetic and para-sympathetic transmission to the dog heart.  Musha, T., Satoh, E., Koyanagawa, H., Kimura, T., Satoh, S.  J. Pharmacol. Exp. Ther., 1989, 250(3), 1087-1091.

• 日本薬理学会
• 日本循環器学会
• 日本心脈管作用物質学会
• 日本生化学会
• 日本薬学会

著書

• Web版 Hybrid book 薬理学演習、佐藤 進、相原弘和、佐藤栄作(分担執筆)、廣川鉄男事務所、2017年
• 新薬理学テキスト　改訂第3版(佐藤進編)、第19章　薬理データの統計学的解析、吉田真、佐藤栄作(分担執筆)、廣川書店、2011年
• CBT対策と演習　薬理学　第2版、薬学教育研究会編(分担執筆)、廣川書店、2010年