薬学部
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研究テーマ
1. 互変異性ピリミジン系複素環化合物の効率的合成法の開発
2. ピリミジン系複素環化合物の機能開発と生物活性
3. 新しい触媒的ラジカル反応の開発
論文など
1. Shimamoto, S.; Kamimura, M.; Nishimura, Y.; Shiraishi, J.; Tomonaga, S.; Do, H.; Katafuchi, A.; Muroya, S.; OHTSUKA, A.; Ijiri, D. Quantitative Analysis of Intracellular Nτ-Methylhistidine Concentration in C2C12 Myotubes by Liquid Chromatography–Tandem Mass Spectrometry. Biosci. Biotechnol. Biochem. accepted.
2. Tansou, R.; Kubo, T.; Nishida, H.; Nishimura, Y.; Mihara, K.; Yanagihara, K.; Seyama, T. Lipid-siRNA Conjugates Targeting High PD-L1 Expression as Potential Novel Immune Checkpoint Inhibitors. Biomolecules 2025, 15, 293.
3. Kubo, T.; Yanagihara, K.; Nishimura, Y.; Iino, Y.; Komatsu, T.; Tansou, R.; Mihara, K.; Seyama, T. Antitumor Effect of Oleoyl-siRNA against Pancreatic Cancer Using a Portal Vein Infusion Liver-Metastatic Mouse Model. Molecular Pharmaceutics 2024, 21, 5115–5125.
4. Nishimura, Y.; Kubo, T.; Shibuya, N.; Cho, H. Fully Substituted Dihydropyrimidines, Pentasubstituted 2-Aryldihydropyrimidines Synthesized by Palladium-catalyzed/copper-mediated Cross-coupling Reaction. Synthesis 2023, 55, 1996–2004.
5. Nishimura, Y.; Kubo, T.; Takayama, S.; Yoshida, H.; Cho, H. Palladium-catalyzed/copper-mediated carbon-carbon cross-coupling reaction for synthesis of 6-unsubstituted 2-aryldihydropyrimidines. RSC Advances 2022, 12, 28113–28122.
6. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Arai, R.; Toguchi, Y.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of 4,4-Disubstituted 3,4-Dihydropyrimidin-2(1H)-ones and -thiones, the Corresponding Products of Biginelli Reaction Using Ketone, and Their Antiproliferative Effect on HL-60 Cells. Chem. Pharm. Bull. 2022, 70, 111–119.
7. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Nakakita, I.; Oguni, M.; Ohta, M.; Arai, R.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells. Tetrahedron Lett. 2021, 65, 152760.
8. Nishimura, Y. Development of efficient synthetic method for tautomeric dihydropyrimidines and analysis of their functionality. YAKUGAKU ZASSHI 2021, 141, 151–161.
9. Kubo, T.; Nishimura, Y.; Sato, Y.; Yanagihara, K.; Seyama, T. Sixteen diffrent types of lipid-conjugated siRNAs containing saturated and unsaturated fatty acids and exhibiting enhanced RNAi potency. ACS Chemical Biology 2021, 16, 150–164.
10. Nishimura, Y.; Kikuchi, H.; Kubo, T.; Gokurakuji, Y.; Nakamura, Y.; Arai, R.; Yuan, B.; Sunaga, K.; Cho, H. Synthesis of 6-unsubstituted 2-oxo, 2-thioxo, 2-amino-3,4-dihydropyrimidines and their antiproliferative effect on HL-60 cells. Tetrahedron Lett. 2020, 61, 151967.
11. Kubo, T.; Nishimura, Y.; Hatori, Y.; Akagi, R.; Mihara, K.; Yanagihara, K.; Seyama, T. Antitumor effect of palmitic acid-conjugated DsiRNAs for colon cancer in a mouse subcutaneous tumor model. Chemical Biology & Drug Design 2019, 93, 570–581.
12. Cho, H.; Nishimura, Y.; Ikeda, H.; Asakura, M.; Toyota, S. Experimental and theoretical studies on thermodynamics and properties of tautomers of 2-substituted 6(4)-methyl-1,4(1,6)-dihydropyrimidine-5-carboxylates. Tetrahedron 2018, 74, 2405–2413.
13. Nishimura, Y.; Kubo, T.; Okamoto, Y.; Cho, H. Convergent synthesis of 4,6-unsubstituted 5-acyl-2-aminodihydropyrimidines using Weinreb amide group. Tetrahedron Lett. 2017, 58, 4236–4239.
14. Nishimura, Y.; Kubo, T.; Okamoto, Y.; Cho, H. Convergent synthesis of 4,6-unsubstituted 5-acyl-2-phenyldihydropyrimidines by substitution reactions of Weinreb amide group of tetrahydropyrimidine. Tetrahedron Lett. 2016, 57, 4492–4495.
15. Nishimura, Y.; Cho, H. Synthesis of 4,6-Unsubstituted 2-Aminodihydropyrimidine-5-carboxylates through Sequential Staudinger/Aza-Wittig/Cyclization Reactions. Synlett 2015, 26, 233–237.
16. Nishimura, M.; Nishimura, Y.; Abe, C.; Kohhata, M. Expression of Substrate Range of Streptomyces Vanillate Demethylase. Biol. Pharm. Bull. 2014, 37, 1564–1568.
17. Nishimura, Y.; Cho, H. Synthesis of 4-unsubstituted dihydropyrimidines having acyl and alkoxycarbony groups at 5- and 6-positions by cyclization-elimination reactions using 1,3-diaza-1,3-butadienes. Tetrahedron Lett. 2014, 55, 411–414.
18. Nishi, H.; Ikunaka, M.; Nishimura, Y. Development of the Novel Stereoselective Synthetic Process for an Optically Active Intermediate of (-)-Ranirestat: Aldose Reductase Inhibitor and its Optical Purity Testing Method by HPLC. 安田女子大学紀要 2014, 42, 337–345.
19. Kubo, T.; Yanagihara, K.; Sato, Y.; Nishimura, Y.; Kondo, S.; Seyama, T. Gene-silencing potency of symmetric and asymmetric lipid-conjugated siRNAs and its correlation with Dicer recognition. Bioconjugate Chemistry 2013, 24, 2045–2057.
20. Kikuchi, H.; Yuan, B.; Nishimura, Y.; Imai, M.; Furutani, R.; Kamoi, S.; Seno, M.; Fukushima, S.; Hazama, S.; Hirobe, C.; Ohyama, K.; Hu, X.-M.; Takagi, N.; Hirano, T.; Toyoda, H. Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. International Journal of Oncology 2013, 43, 1976–1984.
21. Nishimura, Y.; Yasui, Y.; Kobayashi, S.; Yamaguchi, M.; Cho, H. Synthesis of novel 2-phenyl-5-substituted dihydropyrimidines using 2-phenyl-1,3-diaza-1,3-butadienes and electron-deficient olefins. Tetrahedron 2012, 68, 3342–3350.
22. Cho, H.; Nishimura, Y.; Yasui, Y.; Yamaguchi, M. Construction of dihydropyrimidine skeleton using 1,2,4-trisubstituted-1,3-diaza-1,3-butadienes. Tetrahedron Lett. 2012, 53, 1177–1179.
23. Cho, H.; Kwon, E.; Yasui, Y.; Kobayashi, S.; Nishimura, Y.; Yamaguchi, M. Ring cleavage of dihydropyrimidine skeleton. Tetrahedron Lett. 2011, 52, 7185–7188.
24. Nishimura, Y.; Okamoto, Y.; Ikunaka, M.; Ohyama, Y. Synthetic Studies on Novel 1,4-Dihydro-2-methylthio-4,4,6-trisubstituted Pyrimidine-5-carboxylic Acid Esters and Their Tautomers. Chem. Pharm. Bull. 2011, 59, 1458–1466.
25. Nishimura, M.; Kohno, K.; Nishimura, Y.; Inagaki, M.; Davies, J. Characterization of Two Isozymes of Coniferyl Alcohol Dehydrogenase from Streptomyces sp. NL15-2K. Bioscience, Biotechnology, and Biochemistry 2011, 75, 1770–1777.
26. Cho, H.; Nishimura, Y.; Yasui, Y.; Kobayashi, S.; Yoshida, S.; Kwon, E.; Yamaguchi, M. Synthesis of 4-unsubstituted dihydropyrimidines. Nucleophilic substitution at position-2 of dihydropyrimidines. Tetrahedron 2011, 67, 2661–2669.
27. Nishimura, Y.; Kiryu, M.; Suwa, K.; Amemiya, R.; Yamaguchi, M. Gallium Trichloride-Promoted Ethynylation Reaction of 1,4-Dienes. Adv. Synth. Catal. 2008, 350, 1271–1274.
28. Nishimura, Y.; Shiraishi, T.; Yamaguchi, M. (Z)-selective Wittig and Corey-Chaykovsky Reactions of Propargyl Ylides Using Trialkylgallium Bases. Tetrahedron Lett. 2008, 49, 3492–3495.
29. Yamaguchi, M.; Nishimura, Y. Trichlorogallium and Trialkylgalliums in Oganic Synthesis. Chem. Commun. 2008, 35–48.
30. Nishimura, Y.; Miyake, Y.; Amemiya, R.; Yamaguchi, M. Triethylgallium as a Nonnucleophilic Base to Generate Enolates from Ketones. Org. Lett. 2006, 8, 5077–5080.
31. Nishimura, Y.; Amemiya, R.; Yamaguchi, M. α-Ethynylation Reaction of Ketones Using Catalytic Amounts of Trialkylgallium Base. Tetrahedron Lett. 2006, 47, 1839–1843.
32. Amemiya, R.; Suwa, K.; Toriyama, J.; Nishimura, Y.; Yamaguchi, M. One-Step Synthesis of Triethynylvinylmethanes and Tetraethynylmethanes by GaCl3-Promoted Diethynylation of 1,4-Enynes and 1,4-Dienes. J. Am. Chem. Soc. 2005, 127, 8252–8253.
33. Amemiya, R.; Nishimura, Y.; Yamaguchi, M. GaCl3-Catalyzed α-Ethenylation Reaction of Ketone. Synthesis 2004, 1307–1314.
日本薬学会
日本化学会
有機合成化学協会
日本プロセス化学会
受賞歴など
2019年度 日本薬学会中国四国支部奨励賞
2005年度 日本学術振興会特別研究員奨励費(DC2)
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