奥羽大学【薬学部・歯学部】

教員紹介

柏木　良友教授 [Yoshitomo Kashiwagi]

担当授業科目

物理化学Ⅱ/物理化学Ⅲ/製剤学/からだと生命と基礎原理/センサー概論/薬学演習Ⅲ・Ⅳ・Ⅴ・Ⅵ/基礎薬学実習(物理)/物理系実習/薬剤学実習/特別実習

主な研究

主な研究テーマ

電気刺激応答型薬物送達制御システムの構築
有機ニトロキシルラジカル触媒の構造活性相関に関する研究と高活性アルコール酸化触媒の開発
電気化学的手法を利用した高感度センサーの開発

研究論文

Determination of antibiotics by amperometry using N-oxyl, a highly active nitroxyl radical, T. Ono, F. Sato, M. Kumano, S. Komatsu, K. Sugiyama, K. Watanabe, K. Yoshida, Y. Sasano, T. Fujimura, Y. Iwabuchi, Y. Kashiwagi, K. Sato, Anal. Sci., 39, 1771-1775, 2023; doi: 10.1007/s44211-003-00388-4.
Identification of the Optimal Framework for Nitroxyl Radical/Hydroxylamine in Copper-Cocatalyzed Aerobic Alcohol Oxidation, M. Toda, Y. Sasano, M. Takahashi, S. Fujiki, K. Kasabata, T. Ono, K. Sato, Y. Kashiwagi, Y. Iwabuchi, J. Org. Chem., 88, 1434-1444, 2023; doi: 10.1021/acs.joc.2c02327.
Electrochemical Reactions of Highly Active Nitroxyl Radicals with Thiol Compounds, Masayuki Kumano, Kyoko Sugiyama, Fumiya Sato, Sachiko Komatsu, Kazuhiro Watanabe, Tetsuya Ono, Kentaro Yoshida, Yusuke Sasano, Yoshiharu Iwabuchi, Tsutomu Fujimura, Yoshitomo Kashiwagi,* Katsuhiko Sato, Anal. Sci., 39, 369-374, 2023; doi: 10.1007/s44211-00246-9.
Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid), Kentaro Yoshida, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Shigehiro Takahashi, Yoshitomo Kashiwagi, Katsuhiko Sato, Polymers 2022, 14(24), 5349; https://doi.org/10.3390/polym14245349
Electrochemical Polymerization ofNitroxyl Radical Precursor Containing Phenol Side Chain in Aqueous Solution and Its Use in the Electrochemical Analysis of Glucose, Katsuhiko SATO, Masayuki KUMAN0, Kyoko SUGIYAMA, Sachiko KOMATSU, Kazuhiro WATANABE, Ryota IMAHASHI, Tetsuya ONO, Kentaro YOSHIDA, Takenori DAIRAKU, Tsutomu FUJIMURA, and Yoshitomo KASHIWAGI*, BUNSEKI KAGAKU, 71, 191-196, 2022.
Nitroxyl Radical/Copper-Catalyzed Electrooxidation of Alcohols and Amines at Low Potentials, Kyoko Sugiyama, Yusuke Sasano, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi, Katsuhiko Sato, Chem. Pharm. Bull., 69, 1005-1009, 2021.
Electrochemical Sensors Using Organocatalysts and the Electroanalysis of Pharmaceuticals, Katsuhiko Sato, Yoshitomo Kashiwagi, Chemical Sensors, 37, 72-77, 2021.
Chemical reduction of Ag⁺ to Ag employing organic electron donors: evaluation of the effect of Ag⁺-mediated cytosine-cytosine base pairing on the aggregation of Ag nanoparticles, Takenori Dairaku, Rika Kawai, Kanako Nozawa-Kumada, Kentaro Yoshida, Tetsuya Ono, Yoshinori Kondo, Jiro Kondo, Akira Ono, Yoshiyuki Tanaka, Yoshitomo Kashiwagi*, Dalton Trans., 50, 12208-12214, 2021, dio: 10.1039/d1dt01927a.
Catalysis of electro-oxidation of antibiotics by nitroxyl radicals and the electrochemical sensing of vancomycin, Tetsuya Ono, Kyoko Sugiyama, Sachiko Komatsu, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Tsutomu Fujimura, Yusuke Sasano, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi, Kstsuhiko Sato, RSC Adv., 11, 21622-21628, 2021.
Effect of cytosine-Ag⁺-cytosine base pairing on the redox potential of the Ag⁺/Ag couple and the chemical reduction of Ag⁺ to Ag by tetrathiafulvalene, Takenori Dairaku, Rika Kawai, Teppei Kanaba, Tetsuya Ono, Kentaro Yoshida, Hajime Sato, Kanako Nozawa-Kumada, Yoshinori Kondo, Jiro Kondo, Akira Ono, Yoshiyuki Tanaka, Yoshitomo Kashiwagi*, Dalton Trans., 50, 7633-7639, 2021, dio: 10.1039/d1dt00975c.
Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A, Sachiko Komatsu, Yusuke Sasano, Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida, Tetsuya Ono, Yoshiharu Iwabuchi, Tsutomu Fujimura,
Katsuhiko Sato, Yoshitomo Kashiwagi*, Int. J. Electrochem. Sci., 16, 21027, 2021.
Electropolymerization of Azure A and pH sensing using poly(Azure A)-modified electrode, Kyoko Sugiyama, Kazuhiro Watanabe, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato, Anal. Sci., 37, 893-896, 2021, dio: 10.216/analsci.20P341
Voltammetric pH Measurements Using Azure A-containing Layer-by-Layer Film Immobilized Electrode, Kazuhiro Watanabe, Kyoko Sugiyama, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato, Polymers, 12, 2328, 2020.
Adsorption and Release of Rose Bengal on Layer-by-Layer Films of Poly(Vinyl Alcohol) and Poly(Amidoamine) Dendrimers Bearing 4-Carboxyphenylboronic Acid, Kentaro Yoshida, Akane Yamaguchi, Hiroki Midorikawa, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Takaya Sato, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato, Polymers, 12, 1854, 2020.
Decomposition of Glucose-Sensitive Layer-by-Layer Films Using Hemin, DNA, and Glucose Oxidase, Kentaro Yoshida, Yu Kashimura, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Takaya Sato, Yoshitomo Kashiwagi, Katsuhiko Sato, Polymers, 12, 319, 2020.
Electrochemical determination of choline using nortropine-N-oxyl for a non-enzymatic system, Yoshitomo Kashiwagi*, Tetsuya Ono, Fumiya Sato, Masayuki Kumano, Kentaro Yoshida, Takenori Dairakua, Yusuke Sasano, Yoshiharu Iwabuchi, Katsuhiko Sato, Sensing and Bio-Sensing Research, 27, 100302, 2020.
Electrochemical Detection of Triglycerides based on an Enzymatic Reaction and Electrocatalytic Oxidation with Nortropine-N-oxyl, Tetsuya Ono, Katsuhiko Sato, Yusuke Sasano, Kentaro Yoshida, Takenori Dairaku, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi*, Electroanalysis, 31, 603-606, 2019.
Electrochemical oxidation of amines using a nitroxyl radical catalyst and the electroanalysis of lidocaine, Katsuhiko Sato, Tetsuya Ono, Yusuke Sasano, Fumiya Sato, Masayuki Kumano, Kentaro Yoshida, Takenori Dairaku, Yoshiharu Iwabuchi, Yoshitomo Kashiwagi*, Catalysts, 8, 649-656, 2018.
Preparation of hydrogen peroxide sensitive nanofilms by layer-by-layer technique, Kentaro Yoshida, Tetsuya Ono, Takenori Dairaku, Yoshitomo Kashiwagi, Katsuhiko Sato, Nanomaterials, 8, 941-950, 2018.
Preparation of microparticles capable of glucose-induced insulin release under physiological conditions, Kentaro Yoshida, Kazuma Awaji, Seira Shimizu, Miku Iwasaki, Yuki Oide, Megumi Ito, Takenori Dairaku, Tetsuya Ono, Yoshitomo Kashiwagi, Katsuhiko Sato, Polymers, 10, 1164-1177, 2018.
Preparation of Nafion/Polycation Layer-by-Layer Films for Adsorption and Release of Insulin, Kentaro Yoshida, Katsuhiko Sato, Tetsuya Ono, Takenori Dairaku, Yoshitomo Kashiwagi, Polymers, 10, 812-821, 2018.
Construction of PQQ-enzyme Multi-immobilized Electrodes for Electrocatalytic Reduction Formate, Yoshitomo Kashiwagi*, Tetsuya Ono T, Kentaro Yoshida, Toshinori Ito, Nobuki Sakurai, Heterocycles, 96, 1216-1225, 2018.
Electrocatalytic Oxidation of Carbohydrates Mediates by Nitroxyl Radical-modified Electrodes in Aqueous Solution, Tetsuya Ono, Syunki Shimizu, Katsuhiko Sato, Kentaro Yoshida, Takenori Dairaku, Yasuhiro Suzuk, Yoshitomo Kashiwagi*, Electroanalysis, 30, 24-26, 2018.
pH-dependent release of insulin from layer-by-layer-deposited polyelectrolyte microcapsules. Kentaro Yoshida, Tetsuya Ono, Yoshitomo Kashiwagi, Shigehiro Takahashi, Katsuhiko Sato, Jun-ichi Anzai, Polymers, 7, 1269-1278, 2015.
Electrochemical determination of D-glucose using nortropine N-oxyl under physiological conditions, Katsuhiko Sato, Tetsuya Ono, Kentaro Yoshida, Toshinori Ito, Yoshitomo Kashiwagi*, Electoroanalysis, 10, 2272-2274, 2015.
Electrochemical decomposition of layer-by-layer thin films composed of TEMPO-modified poly(acrylic acid) and poly(ethyleneimine), Shigehiro Takahashi, Yu Aikawa, Tomotaka Kudo, Tetsuya Ono, Yoshitomo Kashiwagi, Jun-ichi Anzai, Colloid and Polymer Sciences, 292, 771-776, 2014.
Design of Electrode Providing Preparative Steroselective Synthesis, Tetsuo Osa, Yoshitomo Kashiwagi, Tetsuya Ono, Futoshi Kurashima, Uichi Akiba, Int. J. Soc. Mater. Eng. Resour., 20, 49-53, 2014.