薬剤学Ⅰ(物理薬剤学)、薬剤学Ⅱ(生物薬剤学)、薬物送達システム、薬物相互作用学、TDM・薬物代謝学演習、数学Ⅱ、薬剤学実習、薬学演習Ⅲ・Ⅳ・Ⅴ・Ⅵ 、卒業研究

1.速度論を用いた化学物質の膜透過性評価法の開発

2.経皮的に曝露される化学物質の安全性評価に関する研究

研究論文

1. Stratum corneum function as skin barrier and reservoir in transdermal absorption and penetration of drugs, Sugino M., Journal of Pharmaceutical Science and Technology, Japan, 82, 215-218, (2022).
2. Pharmaceutical properties of Rikkunshito extract suppository and bioequivalence by pharmacokinetic parameters and effectiveness against nausea and vomiting and anorexia in rats, Murata I., Nishiyama T., Kawasaki H., Naito C., Kamata T., Furukawa Y., Iwata M., Sugino M., Inoue Y., Kanamoto I. , Yakugaku Zasshi, 138, 1169-1179, (2018).
3. Safety evaluation of dermal exposure to phthalates: Metabolism-dependent percutaneous absorption, Sugino M., Hatanaka T., Todo H., Mashimo Y., Suzuki T., Kobayashi M., Hosoya O., Jinno H., Juni K., Sugibayashi K., Toxicol. Appl. Pharmacol., 328, 10-17, (2017).
4. A study on an in vitro changeable pH dissolution/permeation system that reflects pH shifts of gastrointestinal tract: a case of a poorly soluble basic drug, Miki R., Hara Y., Imai N., Sugino M., Egawa Y., Hosoya O., Juni K., Seki T., AATEX., 22, 107-114, (2017).
5. Effect of adhesives on the properties of adhesion, drug release and skin permeation of lidocaine tapes, Sugino M., Mikami M., Ishihara T., Hosoya O., Juni K., Yakugaku Zasshi, 135, 977-985, (2015).
6. Influence of NTE activity in skin on percutaneous absorption of sick house syndrome related substances, Hatanaka T., Ogino E., Motosugi N., Takeuchi E., Sakabe K., Sugino M., Juni K., Kimura M., Jpn. J. Clin. Ecol., 24, 88-93, (2015).
7. Effects of the Properties of Creams on Skin Penetration, Inoue Y., Shimura A., Horage M., Maeda R., Murata I., Sugino M., Juni K., Kanamoto I., Int. J. Pharm., 5, 645-654, (2015).
8. Safety prediction of topically exposed biocides using permeability coefficients and the desquamation rate at the stratum corneum, Sugino M., Todo H., Suzuki T., Nakada K., Tsuji K., Tokunaga H., Jinno H., Sugibayashi K., J. Toxicol. Sci., 39, 475-485, (2014).
9. Preparation of polypseudorotaxanes composed of cyclodextrin and polymers in microspheres, Shinohara K., Yamashita M., Uchida W., Okabe C., Oshima S., Sugino M., Egawa Y., Miki R., Hosoya O., Fujihara T., Ishimaru Y., Kishino T., Seki T., Juni K., Chem. Pharm. Bull., 62, 962-966, (2014).

総説

1. 皮膚を介した薬物デリバリー, 杉林堅次,杉野雅浩, 化学工業, 59, 400-406, 2008.
2. 薬物の皮膚透過性と経皮吸収型製剤:角層バリア克服の歴史, 杉野雅浩,藤堂浩明,杉林堅次, 薬学雑誌, 129, 1453-1458, 2009.
3. 香粧品科学・皮膚科学への薬学からの挑戦 ～若手の視点からの提言～, 杉野雅浩,山下浩平, 薬学雑誌, 132, 1209-1210, 2012.

著書

1. 応用が拡がるDDS-人体環境から農業・家電まで-
   第1章,第1節,3,経皮吸収型製剤における放出制御, 杉野雅浩,藤堂浩明,杉林堅次, NTS, 2013.(共著)

日本薬学会、日本薬剤学会、日本分子生物学会、日本臨床腫瘍学会

 

連絡先(メールアドレス; [at]を@に変換して下さい。)

m-sugino[at]pha.ohu-u.ac.jp