歯学部
1. 口腔-腸管連続系における新規プロバイオティクスシーズの開発
偏性嫌気性グラム陰性球菌であるVeillonella(ベイオネラ)属細菌は、ヒト消化器系における常在細菌である。本属細菌のユニークなエネルギー代謝機能をゲノム編集により改良することで、新規う蝕予防プロバイオティクスや、全身免疫系に寄与する腸管プロバイオティクスのシーズとなる育種開発に取り組んでいる。
2. 口腔細菌の新菌種及び新属の確立と提唱
ヒト口腔より分離される偏性嫌気性菌を中心とした系統分類を行っている。未同定細菌の新菌種、新属の確立と提唱を進めることで、口腔マイクロバイオーム情報の拡充を図る。
【著書】
1. (共著)口腔微生物学:感染と免疫ー第7版ー 学建書院
【原著論文】
1. Mashima I, Kamaguchi A, Nakazawa F. The Distribution and Frequency of Oral Veillonella spp. in the Tongue Biofilm of Healthy Yong Adults, Curr Microbiol, 63:403-407, 2011.
2. Mashima I, Nakazawa F. The wire method for generating experimental biofilms formed by oral Streptococcus and Veillonella species, Dent J Heal Sci Univ Hokkaido, 31(2):73-80, 2012.
3. Mashima I, Kamaguchi A, Miyakawa H, Nakazawa F. Veillonella tobetsuensis sp. nov., a novel anaerobic, Gram-negative coccus isolated from human tongue biofilm, Int J Syst Evol Microbiol, 63: 1443-1449, 2013.
4. Mashima I, Nakazawa F. Identification of Veillonella tobetsuensis in Tongue Biofilm by Using a Species-Specific Primer Pair, Anaerobe, 22: 77-81, 2013.
5. Mashima I, Oka Y, Aoki M, Nakazawa F. Application of tea tree oil for disinfection of dental unit waterlines, Dent J Heal Sci Univ Hokkaido, 33(1):1-8, 2014.
6. Mashima I, Nakazawa F. The influence of oral Veillonella species on biofilm formed by Streptococcus species, Anaerobe, 28:54-61, 2014.
7. Mashima I, Fujita M, Nakatsuka Y, Kado T, Furuichi Y, Sulistyani H, Nakazawa F. The Distribution and Frequency of Veillonella spp. associated with Chronic Periodontal Diseases, Int J Curr Microbiol Appl Sci, 4(3):150-160, 2015.
8. Mashima I, Nakazawa F. Draft Genome Sequence of Veillonella tobetsuensis ATCC BAA-2400T Isolated from Human Tongue Biofilm, Genome Announc, 3(4):1-2, 2015.
9. Mashima I, Theodorea CF, Thaweboon B, Thaweboon S, Nakazawa F. Identification of Veillonella Species in the Tongue Biofilm by Using a Novel One-step Polymerase Chain Reaction Method, PLOS ONE, 11(6): e0157516, 2016.
10. Fujita M, Mashima I, Nakazawa F. Monitoring the decontamination efficacy of the novel Poseidon-S disinfectant system in dental unit water lines, J Microbiol, Immunol Infect, 50: 270-276, 2017.
11. Yamazaki K, Mashima I, Nakazawa F, Nakanishi Y, Ochi M. Application of Dental Implants Coated with Titanium Nitride; The Experimental Study with Porphyromonas gingivalis Infection, Int J Curr Microbiol Appl Sci, 6(1):130-142, 2017.
12. Mashima I, Nakazawa F. Role of an Autoinducer-2-like Molecule from Veillonella tobetsuensis in Streptococcus gordonii Biofilm Formation, J Oral biosci, 59: 152-156, 2017.
13. Mashima I, Theodorea CF, Thaweboon B, Thaweboon S, Scannapieco FA, Nakazawa F. Exploring the salivary microbiome of children stratified by the oral hygiene index, PLOS ONE 12(9): e0185274, 2017. The top 10% most cited PLOS ONE papers published in 2017
14. Theodorea CF, Mashima I, Nakazawa F. Prospects of Novel Species of Oral Veillonella in Human Saliva, Adv Biotech Microbiol (Short Communication) 5(4): 555667, 2017.
15. Theodorea CF, Mashima I, Thaweboon B, Thaweboon S, Nakazawa F. Molecular Detection of Oral Veillonella Species in the Saliva of Children with Different Oral Hygiene Statuses, Int J Curr Microbiol Appl Sci 6(7): 449-461,2017.
16. Mashima I, Liao YC, Miyakawa H, Theodorea CF, Thaweboon B, Thaweboon S, Scannapieco FA, Nakazawa F.Veillonella infantium sp. nov., an anaerobic, Gram-stain-negative coccus isolated from tongue biofilms of a Thai child, Int J Syst Evol Microbiol, 68(4):1101-1106, 2018.
17. Mashima I, Liao YC, Sabharwal A, Haase EM, Nakazawa F, Scannapieco FA. Draft genome sequences of 4 strains of recently established novel Veillonella species isolated from human oral cavities, Genome Announc, 12; 6(15): e00259-18, 2018.
18. Mashima I, Miyakawa H, Scannapieco FA, Nakazawa F. Identification of an Early Stage Biofilm Inhibitor from Veillonella tobetsuensis, Anaerobe, 52:86-91, 2018.
19. Mashima I, Djais AA, Haase EM, Scannapieco FA, Otomo M, Saitoh M, Nakazawa F. Establishment of a species-specific primer pair for detecting Veillonella infantium based on the 70-kDa heat shock protein gene dnaK, Anaerobe, 52:79-82, 2018.
20. 眞島いづみ, ヒト口腔領域におけるVeillonella属細菌の系統分類とバイオフィルム形成に関する生態学的研究, IFO Res Commun, 32: 5, 2018.
21. Ichioka Y, Kado T, Mashima I, Nakazawa F, Endo K, Furuichi Y. Effects of chemical treatment as an adjunctive of air abrasive debridement on restoring the surface chemical properties and cytocompatibility of experimentally contaminated titanium surfaces, J Biomed Mater Res B – Appl Biomater, 00B:1-9, 2019.
22. Mashima I, Theodorea CF, Thaweboon B, Thaweboon S, Vichayanrat T, Scannapieco FA, Nakazawa F. Characterization of Salivary Microbiome in Healthy Thai Children, Asian Pac J Trop Med, 12(4): 163-169, 2019.
23. Djais AA, Theodorea CF, Mashima I, Otomo M, Saitoh M, Nakazawa F. Identification and phylogenetic analysis of oral Veillonella species isolated from the saliva of Japanese children, F1000Res 8:616, 2019.
24. Theodorea CF, Djais AA, Mashima I, Otomo M, Saitoh M, Nakazawa F. Phylogenetic study of oral Veillonella isolates from saliva of children in Hokkaido, Dent J Heal Sci Univ Hokkaido 38(2): 37-46, 2019.
25. Mashima I, Akiyama TM, Tomida J, Kutsuna R, Washio J, Takahashi N, Nakazawa F, Sato T, Kawamura Y. Draft genome sequences of two Veillonella tobetsuensis clinical isolates from intraoperative bronchial fluids of elderly patients with pulmonary carcinoma, Microb Resourc Announc 8(38): e00397-19, 2019.
26. Tamai R, Suzuki K, Mashima I, Kiyoura Y. MPMBP down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB but not AP-1 activation, Int Immunopharmacol, 79: 106085, 2020.
27. Yamazaki K, Sato K, Tsuzuno T, Sulijaya B, Mashima I, Kawamura Y, Yamazaki K. Orally administrated pathobionts and commensals have comparable and innocuous systemic effects on germ-free mice, Microb Patho, 140: 103962, 2020.
28. Mashima I, Theodorea CF, Djais AA, Kunihiro T, Kawamura Y, Otomo M, Saitoh M, Tamai R, Kiyoura Y. Veillonella nakazawae sp nov., an anaerobic Gram-negative coccus isolated from the oral cavity of Japanese children, Int J Syst Evol Microbiol, in press, 2021.
29. Yambe N, Tamai R, Mashima I, Kiyoura Y. Etidronate down-regulates Toll-like receptor 2 ligand induced chemokine production by inhibiting My D88 expression and NF-κB activation Immunophar Immunotox, in press, 2021.
30. Mashima I, Theodorea CF, Djais AA, Kunihiro T, Kawamura Y, Otomo M, Saitoh M, Tamai R, Kiyoura Y. Veillonella nakazawae sp nov., an anaerobic Gram-negative coccus isolated from the oral cavity of Japanese children Int J Syst Evol Microbiol, 71(1): 004583, 2021.
31. Mashima I, Nakazawa F, Tamai R, Kiyoura Y. Complete genome sequence of Veillonella nakazawae JCM 33966T (=CCUG 74597T), isolated from the oral cavity of Japanese children Microbial Resourc Announc 10(17): e00279-21, 2021.
32. Mashima I, Liao YC, Lin CH, Nakazawa F, Haase EM, Kiyoura Y, Scannapieco FA. Comparative pan-genome analysis of oral Veillonella species Microorganisms 9: 1775, 2021.
33. Kutsuna R, Mashima I, Akiyama TM, Muramatsu Y, Tomida J, Kawamura Y. Chryseobacterium lecitinasegens sp. nov., a shiderophore-producing bacterium isolated from soil at the bottom of a pond Int J Syst Evol Microbiol 71(12): 005135, 2021.
【総説】
1. Mashima I, Nakazawa F, A review on the characterization of a novel oral Veillonella species, V. tobetsuensis, and its role in oral biofilm formation, J Oral Biosci 55:184-190, 2013.
2. Mashima I, Nakazawa F. The Beginning of Application of Quorum Quenching for Replacing Traditional Antibiotics, Dent J Heal Sci Univ Hokkaido, 33(2):13-16, 2014.
3. Mahima I, Nakazawa F. The interaction between Streptococcus spp. and Veillonella tobetsuensis in oral biofilm formation at early stage, J Bacteriol, 197(13): 2104-2111, 2015.
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